Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Jia, J.; Martin, T.A.; Ye, L.; Jiang, W.G.
    FAP-alpha (fibroblast activation protein-alpha) is involved in the control of human breast cancer cell line growth and motility via the FAK pathway (2014), BMC Cell Biol., 15, 16.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B28 quantitative real-time PCR enzyme expression analysis Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.B28 membrane the enzyme is an integral membrane protein Homo sapiens 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B28 Homo sapiens Q12844
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B28 breast cancer cell FAP-alpha is significantly increased in breast cancer patients with poor outcome and survival Homo sapiens
-
3.4.21.B28 MCF-7 cell
-
 Homo sapiens
-
3.4.21.B28 MDA-MB-231 cell
-
 Homo sapiens
-
3.4.21.B28 additional information quantitative real-time PCR enzyme expression analysis Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B28 FAP-alpha
-
 Homo sapiens
3.4.21.B28 fibroblast activation protein-alpha
-
 Homo sapiens
3.4.21.B28 seprase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.B28 metabolism FAP-alpha is significantly increased in breast cancer patients with poor outcome and survival Homo sapiens
3.4.21.B28 additional information overexpression of FAP-alpha results in a reduction of phosphorylated focal adhesion kinase level in both MCF-7 cells and MDA-MB-231 cells cultured in normal media and serum-free media, while the growth of MDA-MB-231 cells and the adhesion and invasion ability of both MCF-7 cells and MDA-MB-231 cells are not dramatically influenced by FAP-alpha expression Homo sapiens
3.4.21.B28 physiological function in vitro, FAP-alpha promotes proliferation and inhibits migration of breast cancer cells, potentially by regulating the FAK pathway Homo sapiens